TY - JOUR
T1 - Modulation of the cytokine and acute‐phase response to major surgery by recombinant interleukin‐2
AU - Deehan, D. J.
AU - Heys, S. D.
AU - Simpson, W.
AU - Broom, J.
AU - McMillan, D. N.
AU - Eremin, O.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Major surgery suppresses host immune reactivity through alterations in monocyte and T cell‐derived cytokine, eicosanoid and acute‐phase protein release. Recombinant interleukin (IL) 2 augments T lymphocyte and monocyte activity in vitro. Eighteen patients, with localized colorectal cancer, were randomized to receive either recombinant IL‐2 or placebo for 3 days by subcutaneous injection before surgery. Serum levels of IL‐1β, IL‐6, tumour necrosis factor α, soluble IL‐2 receptor, C‐reactive protein (CRP) and albumin were measured, and T lymphocyte surface expression of HLA‐DR and CD25 and neutrophil phagocytosis were determined, before and for 21 days after surgery. Significant augmentation of IL‐6, CRP and soluble IL‐2 receptor production, enhanced expression of activation markers and increased neutrophil activity were found. Recombinant IL‐2 may have a role in ameliorating immunosuppression found after major surgery.
AB - Major surgery suppresses host immune reactivity through alterations in monocyte and T cell‐derived cytokine, eicosanoid and acute‐phase protein release. Recombinant interleukin (IL) 2 augments T lymphocyte and monocyte activity in vitro. Eighteen patients, with localized colorectal cancer, were randomized to receive either recombinant IL‐2 or placebo for 3 days by subcutaneous injection before surgery. Serum levels of IL‐1β, IL‐6, tumour necrosis factor α, soluble IL‐2 receptor, C‐reactive protein (CRP) and albumin were measured, and T lymphocyte surface expression of HLA‐DR and CD25 and neutrophil phagocytosis were determined, before and for 21 days after surgery. Significant augmentation of IL‐6, CRP and soluble IL‐2 receptor production, enhanced expression of activation markers and increased neutrophil activity were found. Recombinant IL‐2 may have a role in ameliorating immunosuppression found after major surgery.
UR - http://www.scopus.com/inward/record.url?scp=0028819488&partnerID=8YFLogxK
U2 - 10.1002/bjs.1800820130
DO - 10.1002/bjs.1800820130
M3 - Article
C2 - 7881967
AN - SCOPUS:0028819488
SN - 0007-1323
VL - 82
SP - 86
EP - 90
JO - British Journal of Surgery
JF - British Journal of Surgery
IS - 1
ER -
