Molecular mechanisms of appetite and obesity: a role for brain AMPK

Pablo B Martínez de Morentin, Adela Urisarri, María L Couce, Miguel López

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite.

Original languageEnglish
Pages (from-to)1697-709
Number of pages13
JournalClinical Science
Issue number19
Early online date23 Aug 2016
Publication statusPublished - 1 Oct 2016

Bibliographical note

This work was supported by the European Community’s Seventh
Framework Programme (FP7/2007-2013) the ObERStress project
[grant number 281854 (to M.L.)]; Xunta de Galicia [grant number
2015-CP079 (to M.L.)]; the Ministerio de Econom´ıa y Competitividad
(MINECO) co-funded by the FEDER Program of EU [grant numbers
SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast (to
M.L.)]; and the CIBER de Fisiopatolog´ıa de la Obesidad y Nutricion´
is an initiative of ISCIII.


  • AMPK
  • energy balance
  • food intake
  • hypothalamus
  • obesity


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