Mouse Model of Invasive Fungal Infection

Donna M. MacCallum*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)


The mouse intravenous (IV) challenge model of Candida albicans invasive fungal infection has been widely used to study the importance of the innate immune system in these infections. This chapter describes this well-characterized model, where fungal cells are administered directly into the mouse bloodstream to initiate a systemic infection. The preparation of tissue samples from infected mice to allow evaluation of disease progression and host responses is also described.

Original languageEnglish
Title of host publicationMouse Models of Innate Immunity
Subtitle of host publicationMethods and Protocols
EditorsIrving C. Allen
Place of PublicationTotowa
PublisherHumana Press
Number of pages9
ISBN (Electronic)9781627034814
ISBN (Print)9781627034807
Publication statusPublished - 2013

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Bibliographical note

Research in the laboratory of DMM is supported by grants from the Wellcome Trust (089930), EC (STRIFE) and National Centre for the Replacement, Reduction and Refinement of Animals in Research (NC3Rs).


  • Candida albicans
  • Immunity
  • Infection
  • Intravenous
  • Organ-specific
  • Virulence


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