The mouse intravenous (IV) challenge model of Candida albicans invasive fungal infection has been widely used to study the importance of the innate immune system in these infections. This chapter describes this well-characterized model, where fungal cells are administered directly into the mouse bloodstream to initiate a systemic infection. The preparation of tissue samples from infected mice to allow evaluation of disease progression and host responses is also described.
|Title of host publication||Mouse Models of Innate Immunity|
|Subtitle of host publication||Methods and Protocols|
|Editors||Irving C. Allen|
|Place of Publication||Totowa|
|Number of pages||9|
|Publication status||Published - 2013|
|Name||Methods in Molecular Biology|
Bibliographical noteResearch in the laboratory of DMM is supported by grants from the Wellcome Trust (089930), EC (STRIFE) and National Centre for the Replacement, Reduction and Refinement of Animals in Research (NC3Rs).
- Candida albicans