MRC Surgical Trial for Gastric Cancer: interim pathology results

I C Talbot, Peter Fayers, J Craven, J W L Fielding, P M Wrigley, A Cuschieri

Research output: Contribution to journalAbstractpeer-review


This trial was established in 1984 to see if radical surgery for gastric cancer could lead to survival figures comparable to the excellent results of Japanese
workers. In the five and a half years since the start of recruitment 246 patients have been randomised out of 478 treated by 47 surgeons in 30 centres; 120 patients have been treated by conventional (RI) gastrectomy and 126 by a
radical operation (R2), with more extensive node excision and removal of spleen and body of pancreas (except when the carcinoma is limited to the antrum).
The histology of 206 cases has been examined and shows invasion to the serosa or subserosa in 63%, compared with the opinion of the surgeon at operation that there was definite or suspected serosal involvement in 64%. Surprisingly, 21% of tumours are TI (early gastric cancer). Sixty five per cent of tumours are Lauren intastinal type and 19% are diffuse. The data concerning node status and
patient survival are incomplete at present. These preliminary findings confirm a close similarity to histological tumour types in other series but show a high proportion of early gastric cancers.
Original languageEnglish
Pages (from-to)A1202
Issue number10
Publication statusPublished - Oct 1990


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