Multifunctional redox catalysts as selective enhancers of oxidative stress

Fiona H. Fry; Andrea L. Holme; Niroshini M. Giles; Gregory I. Giles; Catriona Collins; Kim Holt; Sandra Pariagh; Thomas Gelbrich; Michael B. Hursthouse; Nick J. Gutowski; Claus Jacob

doi:10.1039/b502197a

Multifunctional redox catalysts as selective enhancers of oxidative stress

Fiona H. Fry, Andrea L. Holme, Niroshini M. Giles, Gregory I. Giles, Catriona Collins, Kim Holt, Sandra Pariagh, Thomas Gelbrich, Michael B. Hursthouse, Nick J. Gutowski, Claus Jacob^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.

Original language	English
Pages (from-to)	2579-2587
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	3
Issue number	14
Early online date	9 Jun 2005
DOIs	https://doi.org/10.1039/b502197a
Publication status	Published - 21 Jul 2005
Externally published	Yes

Bibliographical note

Acknowledgements: This work was financially supported by the Wellcome Trust, the Leverhulme Trust, DAART, Exeter Antioxidant Therapeutics Ltd. and the University of Exeter (UK). C. J. acknowledges a Visiting Professorship from the Université de Metz (France). The authors are grateful to Prof. Winyard (Exeter) and Prof. Kirsch (Metz) for helpful discussions and wish to thank BMG for the use of their fluorescent microplate reader. The also acknowledge Drs Pourzand (Bath) and Martin (Bristol) for donating cell cultures.

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10.1039/b502197a

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title = "Multifunctional redox catalysts as selective enhancers of oxidative stress",

abstract = "Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.",

author = "Fry, {Fiona H.} and Holme, {Andrea L.} and Giles, {Niroshini M.} and Giles, {Gregory I.} and Catriona Collins and Kim Holt and Sandra Pariagh and Thomas Gelbrich and Hursthouse, {Michael B.} and Gutowski, {Nick J.} and Claus Jacob",

note = "Acknowledgements: This work was financially supported by the Wellcome Trust, the Leverhulme Trust, DAART, Exeter Antioxidant Therapeutics Ltd. and the University of Exeter (UK). C. J. acknowledges a Visiting Professorship from the Universit{\'e} de Metz (France). The authors are grateful to Prof. Winyard (Exeter) and Prof. Kirsch (Metz) for helpful discussions and wish to thank BMG for the use of their fluorescent microplate reader. The also acknowledge Drs Pourzand (Bath) and Martin (Bristol) for donating cell cultures. ",

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AU - Fry, Fiona H.

AU - Holme, Andrea L.

AU - Giles, Niroshini M.

AU - Giles, Gregory I.

AU - Collins, Catriona

AU - Holt, Kim

AU - Pariagh, Sandra

AU - Gelbrich, Thomas

AU - Hursthouse, Michael B.

AU - Gutowski, Nick J.

AU - Jacob, Claus

N1 - Acknowledgements: This work was financially supported by the Wellcome Trust, the Leverhulme Trust, DAART, Exeter Antioxidant Therapeutics Ltd. and the University of Exeter (UK). C. J. acknowledges a Visiting Professorship from the Université de Metz (France). The authors are grateful to Prof. Winyard (Exeter) and Prof. Kirsch (Metz) for helpful discussions and wish to thank BMG for the use of their fluorescent microplate reader. The also acknowledge Drs Pourzand (Bath) and Martin (Bristol) for donating cell cultures.

PY - 2005/7/21

Y1 - 2005/7/21

N2 - Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.

AB - Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.

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ER -

Multifunctional redox catalysts as selective enhancers of oxidative stress

Abstract

Bibliographical note

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