Multistability of synthetic genetic networks with repressive cell-to-cell communication

Ekkehard Ullner, Aneta Koseska, Jurgen Kurths, Evgenii Volkov, Holger Kantz, Jordi García-Ojalvo

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)


We investigate an experimentally feasible synthetic genetic network consisting of two phase repulsively
coupled repressilators, which evokes multiple coexisting stable attractors with different features. We perform a
bifurcation analysis to determine and classify the dynamical structure of the system. Moreover, some of the
dynamical regimes found, such as inhomogeneous steady states and inhomogeneous limit cycles can further be
associated with artificial cell differentiation. We also report and characterize the emergence of chaotic dynamics
resulting from the intercell coupling.
Original languageEnglish
Article number031904
Number of pages8
JournalPhysical Review. E, Statistical, Nonlinear and Soft Matter Physics
Issue number3
Publication statusPublished - 5 Sept 2008


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