Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert

Rishi Vachaspathy Astakala; Gagan Preet; Bruce Milne; Julius Tibyangye; Valeria Razmilic; Jean Franco Castro; Juan A Asenjo; Barbara Andrews; Rainer Ebel; Marcel Jaspars

doi:10.3390/molecules27217185

Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert

Rishi Vachaspathy Astakala, Gagan Preet, Bruce Milne, Julius Tibyangye, Valeria Razmilic, Jean Franco Castro, Juan A Asenjo, Barbara Andrews, Rainer Ebel, Marcel Jaspars^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.

Original language	English
Article number	7185
Number of pages	12
Journal	Molecules
Volume	27
Issue number	21
Early online date	24 Oct 2022
DOIs	https://doi.org/10.3390/molecules27217185
Publication status	Published - 1 Nov 2022

Bibliographical note

Funding: This work was supported by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., within the projects UIDB/04564/2020 and UIDP/04564/2020.

Data Availability Statement

Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/molecules27217185/s1

Sample Availability: Samples of the compounds are available from the authors.

Keywords

Saccharothrix
mutactimycin
anthracycline
glycocide
anthraquinone
NMR
mass spectrometry
antibiotics
ESKAPE pathogens
bovine mastitis
dairy cattle

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Astakala_etal_M_Mutamycin_AP_A_VoR
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Final published version, 1.79 MBLicence: CC BY

Cite this

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title = "Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert",

abstract = "Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.",

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note = "Funding: This work was supported by national funds from FCT—Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, I.P., within the projects UIDB/04564/2020 and UIDP/04564/2020.",

year = "2022",

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AU - Astakala, Rishi Vachaspathy

AU - Preet, Gagan

AU - Milne, Bruce

AU - Tibyangye, Julius

AU - Razmilic, Valeria

AU - Castro, Jean Franco

AU - Asenjo, Juan A

AU - Andrews, Barbara

AU - Ebel, Rainer

AU - Jaspars, Marcel

N1 - Funding: This work was supported by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., within the projects UIDB/04564/2020 and UIDP/04564/2020.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.

AB - Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.

KW - Saccharothrix

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KW - anthracycline

KW - glycocide

KW - anthraquinone

KW - NMR

KW - mass spectrometry

KW - antibiotics

KW - ESKAPE pathogens

KW - bovine mastitis

KW - dairy cattle

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DO - 10.3390/molecules27217185

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SN - 1420-3049

VL - 27

JO - Molecules

JF - Molecules

IS - 21

M1 - 7185

ER -

Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

Other files and links

Fingerprint

Marine Biodiscovery Centre

Cite this

Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

Other files and links

Fingerprint

Equipment

Marine Biodiscovery Centre

Cite this