Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert

Rishi Vachaspathy Astakala, Gagan Preet, Bruce Milne, Julius Tibyangye, Valeria Razmilic, Jean Franco Castro, Juan A Asenjo, Barbara Andrews, Rainer Ebel, Marcel Jaspars* (Corresponding Author)

*Corresponding author for this work

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Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.
Original languageEnglish
Article number7185
Number of pages12
Issue number21
Early online date24 Oct 2022
Publication statusPublished - 1 Nov 2022

Bibliographical note

Funding: This work was supported by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., within the projects UIDB/04564/2020 and UIDP/04564/2020.

Data Availability Statement

Supplementary Materials: The following supporting information can be downloaded at:

Sample Availability: Samples of the compounds are available from the authors.


  • Saccharothrix
  • mutactimycin
  • anthracycline
  • glycocide
  • anthraquinone
  • NMR
  • mass spectrometry
  • antibiotics
  • ESKAPE pathogens
  • bovine mastitis
  • dairy cattle


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