NADH Regeneration: A Case Study of Pt-catalyzed NAD+ Reduction with H2

Tony Saba, Jianwei Li, Joseph W.H. Burnett, Russell Howe, Panagiotis Kechagiopoulos, Xiaodong Wang* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
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This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.
Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalACS Catalysis
Issue number1
Early online date18 Dec 2020
Publication statusPublished - 1 Jan 2021

Bibliographical note

This work was supported by The Royal Society (ICA\R1\180317).


  • cofactor
  • supported Pt
  • conversion
  • selectivity
  • mass balance
  • by-product


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