Abstract
This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.
Original language | English |
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Pages (from-to) | 283-289 |
Number of pages | 7 |
Journal | ACS Catalysis |
Volume | 11 |
Issue number | 1 |
Early online date | 18 Dec 2020 |
DOIs | |
Publication status | Published - 1 Jan 2021 |
Bibliographical note
ACKNOWLEDGMENTS:This work was supported by The Royal Society (ICA\R1\180317).
Keywords
- cofactor
- supported Pt
- conversion
- selectivity
- mass balance
- by-product