Abstract
BACKGROUND: Various observational studies have suggested that neonatal rotavirus infection confers protection against diarrhea due to subsequent rotavirus infection. We examined the incidence of rotavirus infection and diarrhea during the first 2 years of life among children infected with the G10P[11] rotavirus strain during the neonatal period and those not infected with rotavirus.
METHODS: Children were recruited at birth and were followed up at least twice weekly. Stool samples, collected every 2 weeks for surveillance and at each episode of diarrhea, were screened by enzyme-linked immunosorbent assay and were genotyped by polymerase chain reaction.
RESULTS: Among 33 children infected neonatally with G10P[11] and 300 children not infected with rotavirus, there was no significant difference in the rates of rotavirus-positive diarrhea (rate ratio [RR], 1.05 [95% confidence interval [CI], 0.61-1.79]), moderate or severe rotavirus-positive diarrhea (RR, 1.42 [95% CI, 0.73-2.78]), or asymptomatic rotavirus shedding (RR, 1.25 [95% CI, 0.85-1.83]).
CONCLUSION: Neonatal G10P[11] infection with a strain resembling a vaccine candidate did not confer protection against subsequent rotavirus infection or diarrhea of any severity in this setting.
Original language | English |
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Pages (from-to) | 625-32 |
Number of pages | 8 |
Journal | The journal of infectious diseases |
Volume | 195 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Mar 2007 |
Externally published | Yes |
Keywords
- Adult
- Cohort Studies
- Female
- Humans
- India/epidemiology
- Infant
- Infant, Newborn
- Male
- Rotavirus/classification
- Rotavirus Infections/epidemiology