New nodulopeptins from Nodularia spumigena KAC 66

Marc Schumacher, Neil Wilson, Jioji N. Tabudravu, Christine Edwards, Linda A. Lawton, Cherie Motti, Anthony D. Wright, Marc Diederich, Marcel Jaspars*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC-MS analysis using Marfey's reagent. The bioactivity of the novel compounds was determined.

Original languageEnglish
Pages (from-to)1622-1628
Number of pages7
Issue number5
Early online date26 Nov 2011
Publication statusPublished - 4 Feb 2012

Bibliographical note

M.S. was supported by research grant BFR 06/016 of the Ministère de la Culture, de l’Enseignement supérieur et de la Recherche (Grand-Duchy of Luxembourg). Research at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) is financially supported by the “Recherche Cancer et Sang foundation”, the “Recherches Scientifiques Luxembourg” association, the “Een Haerz fir kriibskrank Kanner” association, the “Action Lions Vaincre le Cancer” association, and by Télévie Luxembourg. We would like to thank Enzo Life Sciences, Lausen, Switzerland for their support. We thank Sharon Kelly for measurement of the CD spectrum. We thank Rut Jordana for the IR measurement


  • Cyanobacteria
  • NF-κB
  • Peptides
  • Polypeptides
  • Spectroscopy
  • Structure determination


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