Nitric oxide in a nutshell: Genetics, physiology and pathology

H. F. Galley*, N. R. Webster

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The idea that nitric oxide gas, known from undergraduate chemistry to be a toxic by-product of car exhausts and cigarettes, and the scourge of anaesthetists as a contaminant of nitrous oxide cylinders, could be a biological mediator, was unthinkable 15 years ago. However, in 1987, it was shown that the elusive endothelium-derived relaxing factor was indeed nitric oxide, produced by mammalian cells, with roles in blood pressure regulation, neurotransmission, immunity and cardiovascular function.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalCurrent Anaesthesia and Critical Care
Issue number4
Publication statusPublished - 1 Aug 1998


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