Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity

Keyphrases

• Gastrointestinal Toxicity 100%
• Risedronate 33%
• Gut Epithelial Cells 33%
• Sterols 16%
• Farnesol 16%
• Prenylation 16%
• Proliferation Inhibition 16%
• Small GTPase 16%
• Apoptosis Inhibition 16%
• Prenylated Proteins 16%
• Postmenopausal Osteoporosis 16%
• Intolerability 16%
• Clodronate 16%
• Human Epithelial Cells 16%
• Etidronate 16%
• Armamentarium 16%
• Irritation 16%
• Geraniol 16%
• Oxidized Cholesterol 16%
• Oral Therapy 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Gastrointestinal Toxicity 100%
• Risedronic Acid 25%
• Postmenopause Osteoporosis 12%
• Geranylgeraniol 12%
• Sterol 12%
• Farnesol 12%
• Low Density Lipoprotein Cholesterol 12%
• Clodronic Acid 12%
• Oxidized Low Density Lipoprotein 12%
• Etidronic Acid 12%
• Guanosine Triphosphatase 12%
• Ulcer 12%

Biochemistry, Genetics and Molecular Biology

• Gastrointestinal Tract 66%
• Low-Density Lipoprotein 33%
• Sterol 33%
• Geranylgeraniol 33%
• Farnesol 33%
• Small GTPase 33%