Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus

Caixia Chen, Xueting Liu, Wael M. Abdel-Mageed, Hui Guo, Weiyuan Hou, Marcel Jaspars, Li Li, Feng Xie, Biao Ren, Qian Wang, Huanqin Dai, Fuhang Song*, Lixin Zhang

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

6 Citations (Scopus)


A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.

Original languageEnglish
Pages (from-to)5762-5765
Number of pages4
JournalOrganic Letters
Issue number22
Early online date25 Oct 2013
Publication statusPublished - 15 Nov 2013

Bibliographical note

This work is supported in part by the National Program on Key Basic Research Project(973 program 2013CB734000), The National Natural Science Foundation of china (81102356, 30901849, 81102369), and the General and Special Program of China Postdoctoral Science Foundation (20110490622, 2012T50149). L. Zhang is an Awardee of the National Distinguished Young scholar Program in China.


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