Abstract
A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.
Original language | English |
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Pages (from-to) | 5762-5765 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 15 |
Issue number | 22 |
Early online date | 25 Oct 2013 |
DOIs | |
Publication status | Published - 15 Nov 2013 |
Bibliographical note
Acknowledgement:This work is supported in part by the National Program on Key Basic Research Project(973 program 2013CB734000), The National Natural Science Foundation of china (81102356, 30901849, 81102369), and the General and Special Program of China Postdoctoral Science Foundation (20110490622, 2012T50149). L. Zhang is an Awardee of the National Distinguished Young scholar Program in China.