Non-mnestic cognitive function in the scopolamine model of Alzheimer's disease

M C  Obonsawin; A Graeme W Robertson; John Robertson Crawford; C  Perera; Shona Walker; L  Blackmore; Fiona Lindsay Mary Parker; J A O  Besson

doi:10.1002/(SICI)1099-1077(199808)13:6<439::AID-HUP19>3.0.CO;2-E

Non-mnestic cognitive function in the scopolamine model of Alzheimer's disease

M C Obonsawin, A Graeme W Robertson, John Robertson Crawford, C Perera, Shona Walker, L Blackmore, Fiona Lindsay Mary Parker, J A O Besson

University of Strathclyde

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0.5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R profile does not have a cholinergic basis. Scopolamine did not impair performance on verbal fluency, the Token Test, Judgment of:line Orientation, finger tapping, the Modified Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. (C) 1998 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	439-449
Number of pages	11
Journal	Human Psychopharmacology-Clinical and Experimental
Volume	13
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1099-1077(199808)13:6<439::AID-HUP19>3.0.CO;2-E
Publication status	Published - Aug 1998

Keywords

scopolamine
muscarinic blockade
senile dementia of the Alzheimer's type
Fuld profile
CARD SORTING TEST
R FULD PROFILE
CHOLINERGIC HYPOTHESIS
HUMAN-MEMORY
NUCLEUS BASALIS
VERBAL FLUENCY
DEMENTIA
TACRINE
DYSFUNCTION
SENSITIVITY

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title = "Non-mnestic cognitive function in the scopolamine model of Alzheimer's disease",

abstract = "The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0.5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R profile does not have a cholinergic basis. Scopolamine did not impair performance on verbal fluency, the Token Test, Judgment of:line Orientation, finger tapping, the Modified Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. (C) 1998 John Wiley & Sons, Ltd.",

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author = "Obonsawin, {M C} and Robertson, {A Graeme W} and Crawford, {John Robertson} and C Perera and Shona Walker and L Blackmore and Parker, {Fiona Lindsay Mary} and Besson, {J A O}",

year = "1998",

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doi = "10.1002/(SICI)1099-1077(199808)13:6<439::AID-HUP19>3.0.CO;2-E",

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AU - Robertson, A Graeme W

AU - Crawford, John Robertson

AU - Perera, C

AU - Walker, Shona

AU - Blackmore, L

AU - Parker, Fiona Lindsay Mary

AU - Besson, J A O

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N2 - The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0.5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R profile does not have a cholinergic basis. Scopolamine did not impair performance on verbal fluency, the Token Test, Judgment of:line Orientation, finger tapping, the Modified Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. (C) 1998 John Wiley & Sons, Ltd.

AB - The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0.5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R profile does not have a cholinergic basis. Scopolamine did not impair performance on verbal fluency, the Token Test, Judgment of:line Orientation, finger tapping, the Modified Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. (C) 1998 John Wiley & Sons, Ltd.

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KW - CHOLINERGIC HYPOTHESIS

KW - HUMAN-MEMORY

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KW - SENSITIVITY

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JO - Human Psychopharmacology-Clinical and Experimental

JF - Human Psychopharmacology-Clinical and Experimental

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ER -

Non-mnestic cognitive function in the scopolamine model of Alzheimer's disease

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Keywords

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