Novel aspects of platelet factor XIII function

Joanne L Mitchell, Nicola J Mutch

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
21 Downloads (Pure)


Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.

Original languageEnglish
Pages (from-to)S17-21
Number of pages5
JournalThrombosis Research
Issue numberSuppl 2
Early online date17 May 2016
Publication statusPublished - May 2016

Bibliographical note

The study was supported by grants FS/11/2/28579 (N.J.M.) from the British Heart Foundation and the University of Aberdeen Development Trust.


  • factor XIII
  • platelets
  • fibrinolysis
  • α2-antiplasmin
  • fibrin


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