TY - JOUR
T1 - Novel Synthetic Strategies for the Development of Tryptophan-Proline Chimeras, Useful Tool for Drug Discovery
AU - De Filippis, Barbara
AU - Fantacuzzi, Marialuigia
AU - Piras, Monica
AU - Baldassarre, Massimiliano
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The de novo design of peptides and proteins represents an innovative tool in the early stage of drug research. Over the last thirty years, many studies have been undertaken to develop new strategies of design and synthesis of peptides with specific conformations. Substituted amino acids exhibit significant biological activity, and play an important role in medicinal chemistry. Proline chimeras in particular, are valuable tools for biological investigations. In the literature several strategies for the synthesis of this chimeras are reported. Here we will focus on Tryptophan-Proline and summarize useful methodologies that can be applied to their preparation.
AB - The de novo design of peptides and proteins represents an innovative tool in the early stage of drug research. Over the last thirty years, many studies have been undertaken to develop new strategies of design and synthesis of peptides with specific conformations. Substituted amino acids exhibit significant biological activity, and play an important role in medicinal chemistry. Proline chimeras in particular, are valuable tools for biological investigations. In the literature several strategies for the synthesis of this chimeras are reported. Here we will focus on Tryptophan-Proline and summarize useful methodologies that can be applied to their preparation.
KW - Peptide
KW - Substituted proline
KW - Synthesis
KW - Tryptophan-Proline chimeras
UR - http://www.scopus.com/inward/record.url?scp=84987754732&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84987754732
SN - 1573-4072
VL - 12
SP - 161
EP - 167
JO - Current Bioactive Compounds
JF - Current Bioactive Compounds
IS - 3
ER -