Nutrigenomics and immune function in fish: new insights from omics technologies

Samuel A. M. Martin* (Corresponding Author), Elzbieta Krol

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

161 Citations (Scopus)
10 Downloads (Pure)


The interplay between nutrition and immune system is well recognised, however the true integration of research between nutrition, animal energy status and immune function is still far from clear. In fish nutrition, especially for species maintained in aquaculture, formulated feeds are significantly different from the natural diet with recent changes in nutrient sources, especially with protein and oil sources now being predominated by terrestrial derived ingredients. Additionally, many feeds are now incorporated to health management and termed functional feeds, which are believed to improve fish health, reduce disease outbreaks and/or improve post-infection recovery. Using new omics technologies, including transcriptomics (microarray and RNA-seq) and proteomics, the impacts of nutrition on the immune system is becoming clearer. By using molecular pathway enrichment analysis, modules of genes can indicate how both local (intestinal) and systemic immune function are being altered. Although great progress has been made to define the changes in host immune function, understanding the interplay between fish nutrition, intestinal microbiome and immune system is only just beginning to emerge.
Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalDevelopmental and Comparative Immunology
Early online date28 Feb 2017
Publication statusPublished - Oct 2017

Bibliographical note

This study was funded by BBSRC grant BB/M026604/1.


  • fasting
  • functional feeds
  • plant proteins
  • vegetable oils
  • gut inflammation
  • transcriptomics


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