Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Xuguang Zhang; Susan C. McGeoch; Ian L. Megson; Sandra M. MacRury; Alexandra M. Johnstone; Prakash Abraham; Donald W. M. Pearson; Baukje De Roos; Grietje Holtrop; Niamh O'Kennedy; Gerald E. Lobley

doi:10.1002/mnfr.201300820

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Xuguang Zhang, Susan C. McGeoch, Ian L. Megson, Sandra M. MacRury, Alexandra M. Johnstone, Prakash Abraham, Donald W. M. Pearson, Baukje De Roos, Grietje Holtrop, Niamh O'Kennedy, Gerald E. Lobley

Research output: Contribution to journal › Article › peer-review

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Abstract

Scope
Inflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this may not be optimal as specific inclusion of other nutrients, such as oats, may add benefit. The effectiveness of such interventions can be tested by examination of MP activation markers.

Methods and results
Subjects (n = 22) with type 2 diabetes participated in a randomized cross-over trial involving 8 wk interventions with either an oat-enriched diet (OAT) or following reinforced SDA. Responses were also compared with preintervention habitual (HAB) intake. OAT reduced the concentrations and proportions of fibrinogen- and tissue factor-related PMP and MMP_11b. The main effect of SDA was to reduce fibrinogen-activated PMP. Regardless of chronic intake, a healthy test meal led to postprandial declines in total PMP as well as tissue factor-, fibrinogen-, and P-selectin-positive PMP.

Conclusion
OAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone.

Original language	English
Pages (from-to)	1322-1332
Number of pages	11
Journal	Molecular Nutrition & Food Research
Volume	58
Issue number	6
Early online date	7 Mar 2014
DOIs	https://doi.org/10.1002/mnfr.201300820
Publication status	Published - Jun 2014

Bibliographical note

This work was funded by the Chief Scientists Office of the Scottish Government by a joint grant to the University of the Highland and Islands, Grampian Health Board, Biomathematics and Statistics Scotland and the Rowett Institute of Nutrition and Health, University of Aberdeen. Additional support was provided by Provexis plc.

Keywords

microparticles
oats
platelets
standard dietary advice
type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mnfr.201300820

Zhang_et_al-2014-Molecular_Nutrition_&_Food_Research
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/
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Baukje de Roos
- School of Medicine, Medical Sciences & Nutrition, The Rowett Institute of Nutrition and Health - Personal Chair
Person: Academic

Cite this

Zhang, X., McGeoch, S. C., Megson, I. L., MacRury, S. M., Johnstone, A. M., Abraham, P., Pearson, D. W. M., De Roos, B., Holtrop, G., O'Kennedy, N., & Lobley, G. E. (2014). Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes. Molecular Nutrition & Food Research, 58(6), 1322-1332. https://doi.org/10.1002/mnfr.201300820

Zhang, X, McGeoch, SC, Megson, IL, MacRury, SM, Johnstone, AM, Abraham, P, Pearson, DWM, De Roos, B, Holtrop, G, O'Kennedy, N & Lobley, GE 2014, 'Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes', Molecular Nutrition & Food Research, vol. 58, no. 6, pp. 1322-1332. https://doi.org/10.1002/mnfr.201300820

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title = "Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes",

abstract = "ScopeInflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this may not be optimal as specific inclusion of other nutrients, such as oats, may add benefit. The effectiveness of such interventions can be tested by examination of MP activation markers.Methods and resultsSubjects (n = 22) with type 2 diabetes participated in a randomized cross-over trial involving 8 wk interventions with either an oat-enriched diet (OAT) or following reinforced SDA. Responses were also compared with preintervention habitual (HAB) intake. OAT reduced the concentrations and proportions of fibrinogen- and tissue factor-related PMP and MMP_11b. The main effect of SDA was to reduce fibrinogen-activated PMP. Regardless of chronic intake, a healthy test meal led to postprandial declines in total PMP as well as tissue factor-, fibrinogen-, and P-selectin-positive PMP.ConclusionOAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone.",

keywords = "microparticles, oats, platelets, standard dietary advice, type 2 diabetes",

author = "Xuguang Zhang and McGeoch, {Susan C.} and Megson, {Ian L.} and MacRury, {Sandra M.} and Johnstone, {Alexandra M.} and Prakash Abraham and Pearson, {Donald W. M.} and {De Roos}, Baukje and Grietje Holtrop and Niamh O'Kennedy and Lobley, {Gerald E.}",

note = "This work was funded by the Chief Scientists Office of the Scottish Government by a joint grant to the University of the Highland and Islands, Grampian Health Board, Biomathematics and Statistics Scotland and the Rowett Institute of Nutrition and Health, University of Aberdeen. Additional support was provided by Provexis plc.",

year = "2014",

month = jun,

doi = "10.1002/mnfr.201300820",

language = "English",

volume = "58",

pages = "1322--1332",

journal = "Molecular Nutrition & Food Research",

issn = "1613-4125",

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number = "6",

}

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T1 - Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

AU - Zhang, Xuguang

AU - McGeoch, Susan C.

AU - Megson, Ian L.

AU - MacRury, Sandra M.

AU - Johnstone, Alexandra M.

AU - Abraham, Prakash

AU - Pearson, Donald W. M.

AU - De Roos, Baukje

AU - Holtrop, Grietje

AU - O'Kennedy, Niamh

AU - Lobley, Gerald E.

N1 - This work was funded by the Chief Scientists Office of the Scottish Government by a joint grant to the University of the Highland and Islands, Grampian Health Board, Biomathematics and Statistics Scotland and the Rowett Institute of Nutrition and Health, University of Aberdeen. Additional support was provided by Provexis plc.

PY - 2014/6

Y1 - 2014/6

N2 - ScopeInflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this may not be optimal as specific inclusion of other nutrients, such as oats, may add benefit. The effectiveness of such interventions can be tested by examination of MP activation markers.Methods and resultsSubjects (n = 22) with type 2 diabetes participated in a randomized cross-over trial involving 8 wk interventions with either an oat-enriched diet (OAT) or following reinforced SDA. Responses were also compared with preintervention habitual (HAB) intake. OAT reduced the concentrations and proportions of fibrinogen- and tissue factor-related PMP and MMP_11b. The main effect of SDA was to reduce fibrinogen-activated PMP. Regardless of chronic intake, a healthy test meal led to postprandial declines in total PMP as well as tissue factor-, fibrinogen-, and P-selectin-positive PMP.ConclusionOAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone.

AB - ScopeInflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this may not be optimal as specific inclusion of other nutrients, such as oats, may add benefit. The effectiveness of such interventions can be tested by examination of MP activation markers.Methods and resultsSubjects (n = 22) with type 2 diabetes participated in a randomized cross-over trial involving 8 wk interventions with either an oat-enriched diet (OAT) or following reinforced SDA. Responses were also compared with preintervention habitual (HAB) intake. OAT reduced the concentrations and proportions of fibrinogen- and tissue factor-related PMP and MMP_11b. The main effect of SDA was to reduce fibrinogen-activated PMP. Regardless of chronic intake, a healthy test meal led to postprandial declines in total PMP as well as tissue factor-, fibrinogen-, and P-selectin-positive PMP.ConclusionOAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone.

KW - microparticles

KW - oats

KW - platelets

KW - standard dietary advice

KW - type 2 diabetes

U2 - 10.1002/mnfr.201300820

DO - 10.1002/mnfr.201300820

M3 - Article

SN - 1613-4125

VL - 58

SP - 1322

EP - 1332

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 6

ER -

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Abstract

Bibliographical note

Keywords

UN SDGs

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Baukje de Roos

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