Observational study comparing intranasal mometasone furoate with oral antihistamines for rhinitis and asthma

David Price, Linda Kemp, Erika Sims, Julie von Ziegenweidt, Prakash Navaratnam, Amanda J Lee, Alison Chisholm, Elizabeth V. Hillyer, Gokul Gopalan

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15 Citations (Scopus)


AIMS: Retrospective database study comparing upper and lower airway-related outcomes for patients with rhinitis and co-morbid asthma receiving mometasone furoate--an intranasal corticosteroid with low systemic bioavailability--or an oral antihistamine. METHODS: 395 patients prescribed intranasal mometasone were matched on 10 demographic and respiratory-related criteria in a 1:2 ratio to 790 patients prescribed oral antihistamine. Asthma and rhinitis control were assessed over one year using predefined composite proxy measures. RESULTS: Asthma control was achieved by 309/395 (78.2%) versus 580/790 (73.4%; p=0.071) patients in the mometasone and antihistamine cohorts, respectively. Rhinitis control was achieved by 293 (74.2%) versus 539 (68.2%; p=0.035), respectively. The adjusted odds ratios for antihistamines, relative to mometasone, were 0.71 (95% CI, 0.52-0.98) for achieving asthma control and 0.74 (95% CI, 0.56-0.97) for achieving rhinitis control. CONCLUSIONS: Patients with rhinitis and co-morbid asthma initiating rhinitis therapy achieved significantly better upper as well as lower airway outcomes with intranasal mometasone than with oral antihistamine.
Original languageEnglish
Pages (from-to)266-273
Number of pages8
JournalPrimary Care Respiratory Journal
Issue number3
Early online date22 Jun 2010
Publication statusPublished - Sept 2010


  • antihistamine
  • asthma
  • control
  • mometasone furoate
  • one airway
  • rhinitis


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