Optimal placement of origins for DNA replication

Jens Karschau, J. Julian Blow, Alessandro P. S. de Moura

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
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DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.
Original languageEnglish
Article number058101
Number of pages5
JournalPhysical Review Letters
Issue number5
Early online date30 Jan 2012
Publication statusPublished - 3 Feb 2012


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