Optimisation of the aqueous precipitation synthesis of silicate-substituted hydroxyapatite

Daniel James Hadden, Jan Skakle, Iain Ronald Gibson

Research output: Chapter in Book/Report/Conference proceedingChapter


Silicon-substituted hydroxyapatite (SiHA) bioceramics are widely used as bone replacement materials. There are various synthesis methods used to produce SiHA samples using different sources of silicon. This study aims to investigate the role of tetraethyl orthosilicate (TEOS) as the silicon source in the precipitation reaction synthesis of silicate-substituted HA. Four different synthesis methods were studied by changing the order of addition of the TEOS solution during the precipitation reaction. XRD and QXRD were used to determine the phase purity of the prepared samples. FTIR and SSNMR were used to assess silicon/silicate substitution in the prepared materials. Of the initial four methods used, only one resulted in a sample that was phase pure. The other three syntheses, which produced biphasic compositions, were modified and a further single phase sample was prepared. Results showed that the final composition is strongly dependant on how and when the TEOS was added during the precipitation reaction.

Original languageEnglish
Title of host publicationBioceramics
EditorsGuy Daculsi, Pierre Layrolle
Place of PublicationZurich, Switzerland
PublisherTrans Tech Publications Ltd
Number of pages4
ISBN (Print)087849457X, 978-0878494576
Publication statusPublished - 30 Mar 2008
Event20th International Symposium on Ceramics in Medicine - Nantes, France
Duration: 24 Oct 200726 Oct 2007

Publication series

NameKey Engineering Materials
PublisherTrans Tech Publications Ltd
ISSN (Print)1013-9826


Conference20th International Symposium on Ceramics in Medicine


  • hydroxyapatite
  • silicate
  • silicon
  • substitution
  • X-ray diffraction


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