Oral Epithelial Dysplasia: Can Quantifiable Morphological Features Help in the Grading Dilemma?

Rasha Abu Eid, Gabriel Landini

Research output: Contribution to conferenceOtherpeer-review


he epithelial lining of the oral cavity can sometimes experience certain changes that put it at a higher risk of undergoing malignant transformation. Such changes present clinically as 'premalignant' lesions that at the histological level feature pathological alterations known as epithelial dysplasia. However, the degree of alteration of tissues is routinely assessed visually, thus introducing an element of subjectivity to the diagnostic process. The aim of this work was to apply objective and quantitative image analysis techniques to one problematic area in histopathological diagnosis: the grading of the severity of epithelial dysplasia. Histopathological diagnosis (which depends to some degree on individual judgement of histological features by an observer) has been shown to be subject to intra-and inter-observer variations that affect the accuracy and reproducibility of the diagnostic process. Therefore, more quantitative methods, which do not depend on human perceptual skills, are preferable. In this paper we present a number of innovative techniques to assess a number of morphological features of different grades of oral epithelial dysplasia.
Original languageEnglish
Number of pages6
Publication statusPublished - 2006
Externally publishedYes
Event1st ImageJ User & Developer Conference - CRP Henri Tudor, Luxembourg, Luxembourg
Duration: 18 May 200619 May 2006


Conference1st ImageJ User & Developer Conference


  • Epithelial dysplasia
  • cell morphometry
  • histopathological diagnosis


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