Abstract
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy development over the past year, highlighting a selection of relevant published literature from a PubMed search covering the year from end of April 2022 to end of April 2023. The selected articles have been arranged in themes. These include 1) molecular regulation of articular cartilage and implications for OA, 2) mechanisms of subchondral bone remodelling, 3) role of synovium and inflammation, 4) role of age-related changes including cartilage matrix stiffening, cellular senescence, mitochondrial dysfunction, metabolic dysfunction, and impaired autophagy, and 5) peripheral mechanisms of OA pain. Progress in the understanding of the cellular and molecular mechanisms responsible for the multiple aspects of OA biology is unravelling novel therapeutic targets for disease modification.
Original language | English |
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Journal | Osteoarthritis and Cartilage |
Early online date | 7 Nov 2023 |
DOIs | |
Publication status | E-pub ahead of print - 7 Nov 2023 |
Bibliographical note
Open Access via the Elsevier agreementThe authors are grateful to Versus Arthritis (grant numbers 20775, 21156, and 21800) supporting their research.