Palmitoylation Controls BK Channel Regulation By Phosphorylation

Lijun Tian, Owen Jeffries, Heather McClafferty, Adam Molyvdas, Iain Rowe, Fozia Saleem, Lie Chen, Michael J. Shipston

Research output: Contribution to journalArticlepeer-review


Large conductance calcium- and voltage- gated potassium (BK) channels are important regulators of physiological homeostasis and their function is potently modulated by protein kinase A (PKA) phosphorylation. PKA regulates the channel through phosphorylation of residues within the intracellular C-terminus of the pore-forming α-subunits. However, how PKA phosphorylation of the α-subunit effects changes in channel activity are unknown...
Original languageEnglish
Pages (from-to)473a
JournalBiophysical Journal
Issue numberSupplement 1
Publication statusPublished - Feb 2009


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