Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy

Kordo Saeed; Ian Gould; Silvano Espositio; Nusreen Ahmad-Saeed; Salman Shaheer Ahmed; Emine Alp; Abhijit M. Bal; Matteo Bassetti; Eric Bonnet; Monica Chan; Geoffrey Coombs; Stephanie Dancer; Michael Z. David; Giuseppe De Simone; Matthew Dryden; Luca Guardabassi; Leif G. Hanitsch; Karolin Hijazi; Renate Krüger; Andie Lee; Rasmus Leistner; Pasquale Pagliano; Elda Righi; Sylke Schneider-Burrus; Robert Leo Skov; Pierre Tattevin; Willem Van Wamel; Margreet C. Vos; Andreas Voss; International Society of Chemotherapy

doi:10.1016/j.ijantimicag.2017.11.002

Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy

Kordo Saeed, Ian Gould, Silvano Espositio, Nusreen Ahmad-Saeed, Salman Shaheer Ahmed, Emine Alp, Abhijit M. Bal, Matteo Bassetti, Eric Bonnet, Monica Chan, Geoffrey Coombs, Stephanie Dancer, Michael Z. David, Giuseppe De Simone, Matthew Dryden, Luca Guardabassi, Leif G. Hanitsch, Karolin Hijazi, Renate Krüger, Andie LeeRasmus Leistner, Pasquale Pagliano, Elda Righi, Sylke Schneider-Burrus, Robert Leo Skov, Pierre Tattevin, Willem Van Wamel, Margreet C. Vos, Andreas Voss, International Society of Chemotherapy

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Abstract

Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.

Original language	English
Pages (from-to)	16-25
Number of pages	10
Journal	International Journal of Antimicrobial Agents
Volume	51
Issue number	1
Early online date	22 Nov 2017
DOIs	https://doi.org/10.1016/j.ijantimicag.2017.11.002
Publication status	Published - Jan 2018

Bibliographical note

Funding: None.
Competing interests: None declared.
Ethical approval: Not required.

Keywords

PVL
CA-MRSA
MSSA
S. aureus
infection control

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© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 922 KBLicence: CC BY-NC-ND

https://www.sciencedirect.com/science/article/pii/S0924857917303941

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Saeed, K., Gould, I., Espositio, S., Ahmad-Saeed, N., Ahmed, S. S., Alp, E., Bal, A. M., Bassetti, M., Bonnet, E., Chan, M., Coombs, G., Dancer, S., David, M. Z., De Simone, G., Dryden, M., Guardabassi, L., Hanitsch, L. G., Hijazi, K., Krüger, R., ... International Society of Chemotherapy (2018). Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy. International Journal of Antimicrobial Agents, 51(1), 16-25. https://doi.org/10.1016/j.ijantimicag.2017.11.002

Saeed, K, Gould, I, Espositio, S, Ahmad-Saeed, N, Ahmed, SS, Alp, E, Bal, AM, Bassetti, M, Bonnet, E, Chan, M, Coombs, G, Dancer, S, David, MZ, De Simone, G, Dryden, M, Guardabassi, L, Hanitsch, LG, Hijazi, K, Krüger, R, Lee, A, Leistner, R, Pagliano, P, Righi, E, Schneider-Burrus, S, Skov, RL, Tattevin, P, Van Wamel, W, Vos, MC, Voss, A & International Society of Chemotherapy 2018, 'Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy', International Journal of Antimicrobial Agents, vol. 51, no. 1, pp. 16-25. https://doi.org/10.1016/j.ijantimicag.2017.11.002

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title = "Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy",

abstract = "Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.",

keywords = "PVL, CA-MRSA, MSSA, S. aureus, infection control",

author = "Kordo Saeed and Ian Gould and Silvano Espositio and Nusreen Ahmad-Saeed and Ahmed, {Salman Shaheer} and Emine Alp and Bal, {Abhijit M.} and Matteo Bassetti and Eric Bonnet and Monica Chan and Geoffrey Coombs and Stephanie Dancer and David, {Michael Z.} and {De Simone}, Giuseppe and Matthew Dryden and Luca Guardabassi and Hanitsch, {Leif G.} and Karolin Hijazi and Renate Kr{\"u}ger and Andie Lee and Rasmus Leistner and Pasquale Pagliano and Elda Righi and Sylke Schneider-Burrus and Skov, {Robert Leo} and Pierre Tattevin and {Van Wamel}, Willem and Vos, {Margreet C.} and Andreas Voss and {International Society of Chemotherapy}",

note = "Funding: None. Competing interests: None declared. Ethical approval: Not required.",

year = "2018",

month = jan,

doi = "10.1016/j.ijantimicag.2017.11.002",

language = "English",

volume = "51",

pages = "16--25",

journal = "International Journal of Antimicrobial Agents",

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AU - Saeed, Kordo

AU - Gould, Ian

AU - Espositio, Silvano

AU - Ahmad-Saeed, Nusreen

AU - Ahmed, Salman Shaheer

AU - Alp, Emine

AU - Bal, Abhijit M.

AU - Bassetti, Matteo

AU - Bonnet, Eric

AU - Chan, Monica

AU - Coombs, Geoffrey

AU - Dancer, Stephanie

AU - David, Michael Z.

AU - De Simone, Giuseppe

AU - Dryden, Matthew

AU - Guardabassi, Luca

AU - Hanitsch, Leif G.

AU - Hijazi, Karolin

AU - Krüger, Renate

AU - Lee, Andie

AU - Leistner, Rasmus

AU - Pagliano, Pasquale

AU - Righi, Elda

AU - Schneider-Burrus, Sylke

AU - Skov, Robert Leo

AU - Tattevin, Pierre

AU - Van Wamel, Willem

AU - Vos, Margreet C.

AU - Voss, Andreas

AU - International Society of Chemotherapy

N1 - Funding: None. Competing interests: None declared. Ethical approval: Not required.

PY - 2018/1

Y1 - 2018/1

N2 - Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.

AB - Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research.

KW - PVL

KW - CA-MRSA

KW - MSSA

KW - S. aureus

KW - infection control

UR - https://doi.org/10.1016/j.ijantimicag.2018.03.005

U2 - 10.1016/j.ijantimicag.2017.11.002

DO - 10.1016/j.ijantimicag.2017.11.002

M3 - Article

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VL - 51

SP - 16

EP - 25

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 1

ER -

Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy

Abstract

Bibliographical note

Keywords

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