Abstract
Erectile dysfunction (ED) due to diabetes mellitus remains difficult to treat medically despite advances in pharmacotherapeutic approaches in the field. This unmet need has resulted in a recent re-focus on the pathophysiology, in order to understand the cellular and molecular mechanisms leading to ED in diabetes. Diabetes-induced ED is often resistant to PDE5 inhibitor treatment, thus there is a need to discover targets that may lead to novel approaches for a successful treatment. The aim of this brief review is to update the reader in some of the latest development on that front, with a particular focus on the role of impaired neuronal blood flow and the formation of advanced glycation endproducts.International Journal of Impotence Research adv
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | International Journal of Impotence Research |
| Volume | 25 |
| Issue number | 1 |
| Early online date | 23 Aug 2012 |
| DOIs | |
| Publication status | Published - Jan 2013 |
Keywords
- advanced glycation end products
- diabetes mellitus
- erectile dysfunction
- hypoxia
- microvessel
- nitric oxide
- vasa nervorum
