Abstract
While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research.
Original language | English |
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Pages (from-to) | 274-286 |
Number of pages | 13 |
Journal | European Journal of Heart Failure |
Volume | 24 |
Issue number | 2 |
Early online date | 3 Nov 2021 |
DOIs | |
Publication status | Published - Feb 2022 |
Bibliographical note
Funding Information:D.D. acknowledges the support from the British Heart Foundation grants PG/15/108/31928 and FS/16/39/32174, the Josephine Lansdell British Medical Association 2015 Award and Tenovus Scotland, G13.10. S.H. acknowledges the support from the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2016-Early HFPEF, 2015-10, and CVON She-PREDICTS, grant 2017-21, CVON-Arena-PRIME, European Union Commission's Seventh Framework programme under grant agreement n. 305507 (HOMAGE) and n. 602904 (FIBROTARGETS). A.R.L. is supported by the Leducq Foundation Cardio-Oncology Network.
Keywords
- Genetics
- Inducible pluripotent stem cell models
- microRNA
- Nervous system
- Oestrogen
- Pathophysiology
- Takotsubo syndrome
- Vascular