Perinatal outcome of monoamniotic twin pregnancies

Karien E. Hack, Jan B. Derks, Arty H. Schaap, Enrico Lopriore, Sjoerd G. Elias, Birgit Arabin, Alex J. Eggink, Krystyna M. Sollie, Ben Willem J. Mol, Hans J. Duvekot, Christine Willekes, Attie T. Go, Corine Koopman-Esseboom, Frank P. Vandenbussche, Gerard H. Visser

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


OBJECTIVE:: To study perinatal mortality and neonatal morbidity in a large cohort of monoamniotic twin pregnancies with special emphasis to the gestational age-specific mortality. METHODS:: The study included monoamniotic twin pregnancies delivered in 10 perinatal centers in the Netherlands between January 2000 and December 2007. RESULTS:: A total of 98 monoamniotic pregnancies were included. The perinatal mortality rate (20 weeks of gestation through 28 days of life) was 19%; after exclusion of fetuses with lethal anomalies, the rate was 17%. After 32 weeks of gestation, only two pregnancies were complicated by perinatal mortality (4%). The incidence of twin-twin transfusion syndrome was 6%. The incidence of congenital heart anomalies and cerebral injury was 4% and 5%, respectively. CONCLUSION:: The current incidence of perinatal mortality in monoamniotic twins is considerably lower than in previous decades, but it is still high and occurs throughout pregnancy.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalObstetrics and Gynecology
Issue number2 PART 1
Publication statusPublished - 1 Feb 2009


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