Peripheral tissue-brain interactions in the regulation of food intake

Miguel López, Sulay Tovar, María J. Vázquez, Lynda M. Williams, Carlos Diéguez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)


More than 70 years ago the glucostatic, lipostatic and aminostatic hypotheses proposed that the central nervous system sensed circulating levels of different metabolites, changing feeding behaviour in response to the levels of those molecules. In the last 20 years the rapid increase in obesity and associated pathologies in developed countries has involved a substantial increase in the knowledge of the physiological and molecular mechanism regulating body mass. This effort has resulted in the recent discovery of new peripheral signals, such as leptin and ghrelin, as well as new neuropeptides, such as orexins, involved in body-weight homeostasis. The present review summarises research into energy balance, starting from the original classical hypotheses proposing metabolite sensing, through peripheral tissue-brain interactions and coming full circle to the recently-discovered role of hypothalamic fatty acid synthase in feeding regulation. Understanding these molecular mechanisms will provide new pharmacological targets for the treatment of obesity and appetite disorders.

Original languageEnglish
Pages (from-to)131-155
Number of pages25
JournalProceedings of the Nutrition Society
Issue number1
Publication statusPublished - 1 Feb 2007


  • Adipose and pancreatic hormones
  • Food intake regulation
  • Gastrointestinal signals
  • Neural control


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