Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of 'healthy obesity'?

Xin-Yu Liu, Deng-Bao Yang, Yan-Chao Xu, Marianne O L Gronning, Fang Zhang, De-Hua Wang, John R Speakman

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Brandt's voles have an annual cycle of body weight and adiposity. These changes can be induced in the laboratory by manipulation of photoperiod. In the present study, male captive bred Brandt's voles aged 35 days were acclimated to a short day (SD) photoperiod (8L:16D) for 70 days. A subgroup of individuals (n=16) were implanted with transmitters to monitor physical activity and body temperature. They were then randomly allocated into long day (LD=16L:8D) (n=19: 8 with transmitters) and SD (n=18: 8 with transmitters) groups for an additional 70 days. We monitored aspects of energy balance, glucose and insulin tolerance (GTT and ITT), body composition and organ fat content after exposure to the different photoperiods. LD voles increased in weight for 35 days and then re-established stability at a higher level. At the end of the experiment LD exposed voles had greater white adipose tissue mass than SD voles (p=0.003). During weight gain they did not differ in their food intake or digestive efficiency. However, daily energy expenditure was significantly reduced in the LD compared to SD animals (ANCOVA: p<0.05) and there was a trend to reduced RMR (P=0.075). Physical activity levels were unchanged. Despite different levels of fat storage, the GTT and ITT responses of SD and LD voles were not significantly different, and these traits were not correlated to body fatness. Hence the photoperiod induced obesity was independent of disruptions to glucose homeostasis, indicating a potential adaptive decoupling of these states in evolutionary time. Fat content in both the liver and muscle showed no significant difference between LD and SD animals. How voles overcome the common negative aspects of fat storage may make them a useful model for understanding the phenomenon of 'healthy obesity'.

Original languageEnglish
Pages (from-to)1357-1366
Number of pages10
JournalDisease Models & Mechanisms
Issue number11
Early online date30 Sept 2016
Publication statusPublished - 2 Nov 2016

Bibliographical note

This work was funded by the Strategic Priority Research Program of the Chinese Academy of Sciences [XDB13030000 to J.R.S.], a small grant to J.R.S. and D.-H.W., and a Great Wall professorship to J.R.S., both from the Chinese Academy of Sciences–Novo Nordisk UK Research Foundation. J.R.S. was also supported by a 1000 Talents professorship and a Wolfson merit award from the Royal Society. D.B.Y. was supported by a project from China Postdoctoral Science Foundation [2013M541078].


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