Abstract
BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.
METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.
RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.
CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 449-452 |
| Number of pages | 4 |
| Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| Volume | 108 |
| Issue number | 7 |
| Early online date | 30 Apr 2014 |
| DOIs | |
| Publication status | Published - Jul 2014 |
Bibliographical note
© The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.Funding: This work was supported through grants from the Wellcome Trust [082786] and Foundation for Innovative New Diagnostics.
Keywords
- African trypanosomiasis
- neuronal specific enolase
- stage
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- Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis
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