Pleomorphic LCIS what do we know? A UK multicenter audit of pleomorphic lobular carcinoma in situ

Yazan A Masannat, Ehab Husain, Rebecca Roylance, Steven D Heys, Pauline J Carder, Hiam Ali, Yasmine Maurice, Sarah E Pinder, Elinor Sawyer, Abeer M Shaaban

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


AIMS: Pleomorphic lobular carcinoma in situ (PLCIS) is a relatively newly described pathological lesion that is distinguished from classical LCIS by its large pleomorphic nuclei. The lesion is uncommon and its appropriate management has been debated. The aim of this study is to review data from a large series of PLCIS to examine its natural history in order to guide management plans.

MATERIALS AND METHODS: Comprehensive pathology data were collected from two cohorts; one from a UK multicentre audit and the other a series of PLCIS cases identified from within the GLACIER study cohort. 179 cases were identified of whom 176 had enough data for analysis.

RESULTS: Out of these 176 cases, 130 had invasive disease associated with PLCIS, the majority being of lobular type (classical and/or pleomorphic). A high incidence of histological grade 2 and 3 invasive cancers was noted with a predominance of ER positive and HER-2 negative malignancy. When PLCIS was the most significant finding on diagnostic biopsy the upgrade to invasive disease on excision was 31.8%, which is higher than pooled data for classical LCIS and DCIS.

CONCLUSION: The older age at presentation, high grade of upgrade to invasive cancer, common association with higher grade tumours suggest that PLCIS is an aggressive form of insitu disease. These findings support the view that PLCIS is a more aggressive form of lobular in situ neoplasia and supports the tendency to treat akin to DCIS.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
Early online date5 Jan 2018
Publication statusPublished - 30 Apr 2018

Bibliographical note

Conflict of interest: No Conflict of interest: All authors don't have any financial or personal relationships with other people or organisations that could inappropriately influence (bias) their work.


  • Breast cancer
  • Lobular cancer in situ
  • Pleomorphic lobular carcinoma in situ


Dive into the research topics of 'Pleomorphic LCIS what do we know? A UK multicenter audit of pleomorphic lobular carcinoma in situ'. Together they form a unique fingerprint.

Cite this