Polyamine sensitization in offshore workers handling drilling muds

Anthony Ormerod, R A Wakeel, T A Mann, Alan Main, R D Aldridge

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Oil-based mud, a complex mixture containing amines in emulsifiers, is used in offshore drilling operations. It is a skin irritant that occasionally gives rise to allergic contact sensitivity. In patch testing patients with allergy to drilling mud, we have identified polyamine (diethylenetriamine and triethylenetetramine) sensitivity in 5 patients. All 5 patients were also allergic to emulsifiers. These emulsifiers are cross-linked fatty acid amido-amines, in which unreacted amine groups are thought to cross-sensitize with these constituent polyamines. Cross-reactivity between ethylenediamine, diethylenetetramine and triethylenetetramine was found in 9 subjects.
Original languageEnglish
Pages (from-to)326-329
Number of pages4
JournalContact Dermatitis
Issue number5
Publication statusPublished - 1 Nov 1989


  • Adult
  • Chemical Industry
  • Dermatitis, Contact
  • Dermatitis, Occupational
  • Emulsions
  • Ethylenediamines
  • Humans
  • Lubrication
  • Male
  • Middle Aged
  • Mineral Oil
  • Petroleum
  • Polyamines
  • Triethylenetetramine
  • drilling fluid
  • diethylenetriamine
  • triethylnetetramine
  • ethylenediamine
  • oil based mud
  • irritant contact dermatitis
  • allergic contact dermatitis
  • occupational
  • North Sea
  • oil and gas industry


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