TY - JOUR
T1 - POPDC proteins as potential novel therapeutic targets in cancer
AU - Amunjela, Johanna N
AU - Tucker, Steven J
N1 - We would like to thank the University of Aberdeen College of Life Sciences and Medicine for funding our research.
PY - 2016/12
Y1 - 2016/12
N2 - Popeye domain-containing (POPDC) proteins are a novel class of cAMP-binding molecules that affect cancer cell behaviour and correlate with poor clinical outcomes. They are encoded by the POPDC genes POPDC1, POPDC2, and POPDC3. The deletion of POPDC genes and the suppression of POPDC proteins correlate with enhanced cancer cell proliferation, migration, invasion, metastasis, drug resistance, and poor patient survival in various human cancers. Overexpression of POPDC proteins inhibits cancer cell migration and invasion in vitro. POPDC proteins present promising anticancer therapeutic targets and here we review their roles in promoting cancer progression and highlight their potential as anticancer therapeutic targets.
AB - Popeye domain-containing (POPDC) proteins are a novel class of cAMP-binding molecules that affect cancer cell behaviour and correlate with poor clinical outcomes. They are encoded by the POPDC genes POPDC1, POPDC2, and POPDC3. The deletion of POPDC genes and the suppression of POPDC proteins correlate with enhanced cancer cell proliferation, migration, invasion, metastasis, drug resistance, and poor patient survival in various human cancers. Overexpression of POPDC proteins inhibits cancer cell migration and invasion in vitro. POPDC proteins present promising anticancer therapeutic targets and here we review their roles in promoting cancer progression and highlight their potential as anticancer therapeutic targets.
U2 - 10.1016/j.drudis.2016.07.011
DO - 10.1016/j.drudis.2016.07.011
M3 - Article
SN - 1359-6446
VL - 21
SP - 1920
EP - 1927
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 12
ER -
