Abstract
The human alpha-7 neuronal nicotinic receptor subunit (CHRNA7) gene, located at chromosome 15q13.2, represents a strong candidate gene for schizophrenia, We have examined an (AC)n dinucleotide repeat in intron 2 of the CHRNA7 gene, which was previously shown to be strongly linked with schizophrenia, using both population-based and family-based association studies. In the population-based study, no significant differences between the genotype and allele frequency distributions in schizophrenia patients and control subjects were observed after correction for multiple testing, although a nominally significant association between the most common allele and schizophrenia was observed (P=0.023, uncorrected for multiple testing). In the family-based study, there is no significant over-transmission (Transmitted/Non-transmitted: 61/50) of the same allele in 160 family trios. Overall, our results do not support a major role for the (AC)n dinucleotide repeat in schizophrenia susceptibility in Han Chinese. Further large-scale genetic studies based on a set of single nucleotide polymorphisms (SNPs) that fully characterize the linkage disequilibrium patterns at the CHRNA7 gene are necessary to determine the relevance of this gene as a risk factor for schizophrenia susceptibility. (c) 2006 Elsevier B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 222-227 |
Number of pages | 6 |
Journal | Schizophrenia Research |
Volume | 84 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - Jun 2006 |
Keywords
- schizophrenia
- CHRNA7
- Han Chinese
- association
- TDT
- linkage disequilibrium
- chromosome 15Q13-14
- partial duplication
- brain
- locus
- deficit
- smoking
- markers
- regon