Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Samira Anwar; Mintu Nath; Aarti Patel; Helena Lee; Samantha Brown; Irene Gottlob; Frank A. Proudlock

doi:10.1097/IAE.0000000000002622

Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Samira Anwar (Corresponding Author), Mintu Nath, Aarti Patel, Helena Lee, Samantha Brown, Irene Gottlob, Frank A. Proudlock

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).

Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.

Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.

Conclusions: Foveal width is independent of GA and BW with potential in ROP
screening assessment using HH-OCT. Foveal morphology could be graded in
prematurity during development, with possible implications for future management of preterm infants.

Original language	English
Pages (from-to)	1592-1602
Number of pages	11
Journal	Retina
Volume	40
Issue number	8
Early online date	24 Jul 2019
DOIs	https://doi.org/10.1097/IAE.0000000000002622
Publication status	Published - Aug 2020

Bibliographical note

Financial Support: Medical Research Council, London, UK (grant number:
MR/N004566/1 and MR/J004189/1), Ulverscroft Foundation, Leicester, UK,
Nystagmus Network UK.

Acknowledgements: The authors acknowledge the assistance of Deputy Sister
Hima Thanki in assisting with the acquisition of HH-OCT images and the Staff of the University Hospitals of Leicester Neonatal Service in supporting the infants during the imaging sessions.

Keywords

Foveal Morphology
hand-held Optical Coherence Tomography
prematurity
preterm infant
retinopathy of prematurity
FINE-STRUCTURE
AVASCULAR ZONE
BIRTH-WEIGHT
MACULAR FINDINGS
foveal morphology
CHILDREN
GESTATIONAL-AGE
hand-held optical coherence tomography
THICKNESS

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POTENTIAL_UTILITY_OF_FOVEAL_MORPHOLOGY_IN_PRETERM_VOR
This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
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Cite this

@article{f01a0aa9de8445d38126d99ca7873d47,

title = "Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening",

abstract = "Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.Conclusions: Foveal width is independent of GA and BW with potential in ROPscreening assessment using HH-OCT. Foveal morphology could be graded inprematurity during development, with possible implications for future management of preterm infants.",

keywords = "Foveal Morphology, hand-held Optical Coherence Tomography, prematurity, preterm infant, retinopathy of prematurity, FINE-STRUCTURE, AVASCULAR ZONE, BIRTH-WEIGHT, MACULAR FINDINGS, foveal morphology, CHILDREN, GESTATIONAL-AGE, hand-held optical coherence tomography, THICKNESS",

author = "Samira Anwar and Mintu Nath and Aarti Patel and Helena Lee and Samantha Brown and Irene Gottlob and Proudlock, {Frank A.}",

note = "Financial Support: Medical Research Council, London, UK (grant number: MR/N004566/1 and MR/J004189/1), Ulverscroft Foundation, Leicester, UK, Nystagmus Network UK. Acknowledgements: The authors acknowledge the assistance of Deputy Sister Hima Thanki in assisting with the acquisition of HH-OCT images and the Staff of the University Hospitals of Leicester Neonatal Service in supporting the infants during the imaging sessions.",

year = "2020",

month = aug,

doi = "10.1097/IAE.0000000000002622",

language = "English",

volume = "40",

pages = "1592--1602",

journal = "Retina",

issn = "0275-004X",

publisher = "Lippincott Williams and Wilkins",

number = "8",

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TY - JOUR

T1 - Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

AU - Anwar, Samira

AU - Nath, Mintu

AU - Patel, Aarti

AU - Lee, Helena

AU - Brown, Samantha

AU - Gottlob, Irene

AU - Proudlock, Frank A.

N1 - Financial Support: Medical Research Council, London, UK (grant number: MR/N004566/1 and MR/J004189/1), Ulverscroft Foundation, Leicester, UK, Nystagmus Network UK. Acknowledgements: The authors acknowledge the assistance of Deputy Sister Hima Thanki in assisting with the acquisition of HH-OCT images and the Staff of the University Hospitals of Leicester Neonatal Service in supporting the infants during the imaging sessions.

PY - 2020/8

Y1 - 2020/8

N2 - Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.Conclusions: Foveal width is independent of GA and BW with potential in ROPscreening assessment using HH-OCT. Foveal morphology could be graded inprematurity during development, with possible implications for future management of preterm infants.

AB - Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.Conclusions: Foveal width is independent of GA and BW with potential in ROPscreening assessment using HH-OCT. Foveal morphology could be graded inprematurity during development, with possible implications for future management of preterm infants.

KW - Foveal Morphology

KW - hand-held Optical Coherence Tomography

KW - prematurity

KW - preterm infant

KW - retinopathy of prematurity

KW - FINE-STRUCTURE

KW - AVASCULAR ZONE

KW - BIRTH-WEIGHT

KW - MACULAR FINDINGS

KW - foveal morphology

KW - CHILDREN

KW - GESTATIONAL-AGE

KW - hand-held optical coherence tomography

KW - THICKNESS

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U2 - 10.1097/IAE.0000000000002622

DO - 10.1097/IAE.0000000000002622

M3 - Article

C2 - 31356497

SN - 0275-004X

VL - 40

SP - 1592

EP - 1602

JO - Retina

JF - Retina

IS - 8

ER -

Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Abstract

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Mintu Nath

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Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

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Bibliographical note

Keywords

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