Pregnancy outcome after treatment for cervical intraepithelial neoplasia

Smruta Shanbhag, Heather Clark, Vkc Timmaraju, Siladitya Bhattacharya, Margaret Cruickshank

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


OBJECTIVE: To estimate the rate of spontaneous preterm delivery and preterm premature rupture of membranes (PROM) in women with cervical intraepithelial neoplasia (CIN) 3. METHODS: This retrospective cohort analysis was performed on routinely collected Scottish national data. The exposed cohort comprised all women with CIN3; the unexposed cohort were women with no record of CIN. Further comparisons were made within the exposed cohort based on the type of treatment they had for CIN3. The primary outcomes were spontaneous preterm delivery and preterm PROM in their first pregnancies. RESULTS: Women with CIN3 were significantly more likely to have spontaneous preterm deliveries (11% compared with 6%, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.29-1.80, P
Original languageEnglish
Pages (from-to)727-735
Number of pages9
JournalObstetrics & Gynecology
Issue number4
Publication statusPublished - Oct 2009


  • ablation techniques
  • adult
  • case-control studies
  • cervical intraepithelial neoplasia
  • cohort studies
  • conization
  • electrosurgery
  • female
  • fetal membranes, premature rupture
  • humans
  • middle aged
  • odds ratio
  • pregnancy
  • premature birth
  • registries
  • retrospective studies
  • uterine cervical neoplasms
  • young adult


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