TY - JOUR
T1 - Premorbid adjustment, symptom development and quality of life in first episode psychosis
T2 - A systematic review and critical reappraisal
AU - MacBeth, A.
AU - Gumley, A.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2008/2
Y1 - 2008/2
N2 - Objective: To systematically review the relationship of premorbid adjustment to symptomatology in first episode psychosis (FEP), taking into account the influence of duration of untreated psychosis (DUP). Method: Electronic databases were searched to identify relevant studies. Results: A variety of approaches to the reporting of premorbid adjustment were identified. There was no significant association between premorbid adjustment and DUP, supporting the proposition that they are independent constructs. The effect of premorbid adjustment upon positive symptomatology was negligible. Premorbid adjustment had a modest effect upon negative symptoms and quality of life, increasing over duration of follow-up. Conclusion: Premorbid adjustment remains a valid construct in the study of FEP. Both premorbid adjustment and DUP confer independent effects on aspects of symptomatology in FEP. Results for premorbid adjustment are similar to previous findings in more chronic samples. The potential for conceptualizing premorbid functioning by developmental, academic/social and typological approaches is currently underexploited.
AB - Objective: To systematically review the relationship of premorbid adjustment to symptomatology in first episode psychosis (FEP), taking into account the influence of duration of untreated psychosis (DUP). Method: Electronic databases were searched to identify relevant studies. Results: A variety of approaches to the reporting of premorbid adjustment were identified. There was no significant association between premorbid adjustment and DUP, supporting the proposition that they are independent constructs. The effect of premorbid adjustment upon positive symptomatology was negligible. Premorbid adjustment had a modest effect upon negative symptoms and quality of life, increasing over duration of follow-up. Conclusion: Premorbid adjustment remains a valid construct in the study of FEP. Both premorbid adjustment and DUP confer independent effects on aspects of symptomatology in FEP. Results for premorbid adjustment are similar to previous findings in more chronic samples. The potential for conceptualizing premorbid functioning by developmental, academic/social and typological approaches is currently underexploited.
KW - first-episode psychosis
KW - premorbid adjustment
KW - systematic review
KW - duration of untreated psychosis
KW - outcome
UR - http://www.scopus.com/inward/record.url?scp=38049136867&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0447.2007.01134.x
DO - 10.1111/j.1600-0447.2007.01134.x
M3 - Article
AN - SCOPUS:38049136867
SN - 0001-690X
VL - 117
SP - 85
EP - 99
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
IS - 2
ER -