Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)

N. Maina; J. M. Ngotho; T. Were; J. K. Thuita; D. M. Mwangangi; J. M. Kagira; J. M. Ndung'u; Jeremy M Sternberg

doi:10.1128/IAI.72.5.3063-3065.2004

Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)

N. Maina, J. M. Ngotho, T. Were, J. K. Thuita, D. M. Mwangangi, J. M. Kagira, J. M. Ndung'u, Jeremy M Sternberg

Aberdeen Centre For Environmental Sustainability

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

Original language	English
Pages (from-to)	3063-3065
Number of pages	2
Journal	Infection and Immunity
Volume	72
Issue number	5
DOIs	https://doi.org/10.1128/IAI.72.5.3063-3065.2004
Publication status	Published - 2004

Keywords

CENTRAL-NERVOUS-SYSTEM
TUMOR-NECROSIS-FACTOR
AFRICAN TRYPANOSOMIASIS
NITRIC-OXIDE
INTERFERON-GAMMA
MICE
ACTIVATION

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10.1128/IAI.72.5.3063-3065.2004

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title = "Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)",

abstract = "A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.",

keywords = "CENTRAL-NERVOUS-SYSTEM, TUMOR-NECROSIS-FACTOR, AFRICAN TRYPANOSOMIASIS, NITRIC-OXIDE, INTERFERON-GAMMA, MICE, ACTIVATION",

author = "N. Maina and Ngotho, {J. M.} and T. Were and Thuita, {J. K.} and Mwangangi, {D. M.} and Kagira, {J. M.} and Ndung'u, {J. M.} and Sternberg, {Jeremy M}",

year = "2004",

doi = "10.1128/IAI.72.5.3063-3065.2004",

language = "English",

volume = "72",

pages = "3063--3065",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "5",

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TY - JOUR

T1 - Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)

AU - Maina, N.

AU - Ngotho, J. M.

AU - Were, T.

AU - Thuita, J. K.

AU - Mwangangi, D. M.

AU - Kagira, J. M.

AU - Ndung'u, J. M.

AU - Sternberg, Jeremy M

PY - 2004

Y1 - 2004

N2 - A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

AB - A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

KW - CENTRAL-NERVOUS-SYSTEM

KW - TUMOR-NECROSIS-FACTOR

KW - AFRICAN TRYPANOSOMIASIS

KW - NITRIC-OXIDE

KW - INTERFERON-GAMMA

KW - MICE

KW - ACTIVATION

U2 - 10.1128/IAI.72.5.3063-3065.2004

DO - 10.1128/IAI.72.5.3063-3065.2004

M3 - Article

SN - 0019-9567

VL - 72

SP - 3063

EP - 3065

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)

Abstract

Keywords

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