Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation

Anthony Ormerod, A Kobza Black, J Dawes, R D Murdoch, O Koro, R M Barr, M W Greaves

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32 Citations (Scopus)


Six patients with acquired primary cold urticaria and six normal control subjects were challenged with a 5-minute immersion of an arm in cold water, at 10 degrees C, to induce cold urticaria. Venous blood draining the arm was sampled before and at 5 and 20 minutes after challenge. Prostaglandin D2 levels in the serum increased significantly after cold challenge but did not correlate with the severity of the urticaria. Significant elevations in histamine after cold challenge tended to be higher in the patients with a low threshold to cold reaction. Two markers of platelet activation, platelet factor 4 and beta-thromboglobulin, remained at basal levels 5 minutes and 20 minutes after challenge.
Original languageEnglish
Pages (from-to)586-589
Number of pages4
JournalJournal of Allergy and Clinical Immunology
Issue number4
Publication statusPublished - 1 Oct 1988


  • Adult
  • Blood Platelets
  • Cold Temperature
  • Histamine Release
  • Humans
  • Middle Aged
  • Platelet Factor 4
  • Prostaglandin D2
  • Urticaria
  • beta-Thromboglobulin
  • PF4, Platelet factor 4
  • ßTG, ß-Thromboglobulin
  • PGD2, Prostaglandin D2
  • PAF, Platelet activating factor
  • EDTA, Ethylenediaminetetraacetic acid
  • RIA, Radioimmunoassay


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