Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes

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Increased incidence in obesity is reaching epidemic proportions and is
placing a major burden on the healthcare systems in developed countries.
Obesity is a major risk factor for the development of type 2 diabetes, metabolic
syndrome, cardiovascular disease and cancer. Thus, the search for
molecules that regulate the development of obesity and its associated pathologies
is ongoing. Protein tyrosine phosphatase 1B (PTP1B) has been
found to be a major regulator of body fat stores, energy balance, and insulin
sensitivity in vivo. Increased expression of PTP1B is associated with
insulin resistance in rodents and humans and deletion of PTP1B leads to
leanness and insulin sensitivity in rodents, suggesting that PTP1B may be a
very attractive molecular target for anti-obesity, anti-diabetic agents.
Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalActa Medica Saliniana
Issue number1
Publication statusPublished - 1 Dec 2009


  • diabetes
  • obesity


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