Abstract
A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 μM, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity.
Original language | English |
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Pages (from-to) | 2633-2637 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 73 |
Issue number | 18 |
Early online date | 21 Mar 2017 |
DOIs | |
Publication status | Published - 4 May 2017 |
Bibliographical note
AcknowledgementsThis work was supported by the EU seventh Framework Programme Project ‘PharmaSea’ (Grant agreement no. 312184). BFM acknowledges funding from the Portuguese Foundation for Science and Technology (CONT_DOUT/11/UC/405/10150/18/2008), and thanks DIPC and CFM (UPV/EHU) and the Laboratory for Advanced Computation (University of Coimbra) for support.
Keywords
- LCMS
- NMR
- Pseudoalteromonas
- Pseudochelin A
- Siderophore