Putrescine bisamides from Aglaia gigantea

N.D. Tu, R. Edrada, R. Ebel, V. Wray, W. Frank, T.D. Anh, H.L. Wen, P. Proksch

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Phytochemical analysis of the leaves of Aglaia gigantea collected in Vietnam yielded three cinnamoyl putrescine bisamide derivatives, which included the known compound dasyclamide (1), as well as two new natural products, gigantamide A (2) and grandiamide D (3). In this study, the structure of dasyclamide (1) was confirmed by X-ray crystallography. The structures of the two new alkaloids, gigantamide A (2) and grandiamide D (3), were elucidated through extensive 1D and 2D NMR spectroscopy and analysis of their mass spectrometric (ESIMS, HRQTOFMS) data. The absolute configuration of grandiamide D (3) was determined via Mosher ester derivatization.
Original languageEnglish
Pages (from-to)1640-1643
Number of pages4
JournalJournal of Natural Products
Issue number10
Publication statusPublished - 1 Oct 2007


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