Qualitative, Semi-quantitative, and Quantitative Simulation of the Osmoregulation System in Yeast

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In this paper we demonstrate how Morven, a computational framework which can perform qualitative, semi-quantitative, and quantitative simulation of dynamical systems using the same model formalism, is applied to study the osmotic stress response pathway in yeast. First the Morven framework itself is briefly introduced in terms of the model formalism employed and output format. We then built a qualitative model for the biophysical process of the osmoregulation in yeast, and a global qualitative-level picture was obtained through qualitative simulation of this model. Furthermore, we constructed a Morven model based on existing quantitative model of the osmoregulation system. This model was then simulated qualitatively, semi-quantitatively, and quantitatively. The obtained simulation results are presented with an analysis. Finally the future development of the Morven framework for modelling the dynamic biological systems is discussed.
Original languageEnglish
Pages (from-to)40-50
Number of pages11
Early online date9 Apr 2015
Publication statusPublished - May 2015

Bibliographical note

WP and GMC are supported by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative. WP is also supported by the Researcher International Networking Grant (RING) grant from the British Council.


  • osmotic stress response
  • Semi-quantitative simulation
  • qualitative simulation


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