Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome

Satnam Singh; Roger Beadle; Donnie Cameron; Amelia Rudd; Maggie Bruce; Baljit Jagpal; Konstantin Schwarz; Gemma Brindley; Fergus Mckiddie; Peter Nightingale; Chim Lang; Dana Dawson; Michael Frenneaux

doi:10.2217/fca.14.62

Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome

Satnam Singh, Roger Beadle, Donnie Cameron, Amelia Rudd, Maggie Bruce, Baljit Jagpal, Konstantin Schwarz, Gemma Brindley, Fergus Mckiddie, Peter Nightingale, Chim Lang, Dana Dawson, Michael Frenneaux

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

ABSTRACT Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.

Original language	English
Pages (from-to)	693-698
Number of pages	6
Journal	Future cardiology
Volume	10
Issue number	6
DOIs	https://doi.org/10.2217/fca.14.62
Publication status	Published - Nov 2014

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10.2217/fca.14.62

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title = "Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome",

abstract = "ABSTRACT Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.",

author = "Satnam Singh and Roger Beadle and Donnie Cameron and Amelia Rudd and Maggie Bruce and Baljit Jagpal and Konstantin Schwarz and Gemma Brindley and Fergus Mckiddie and Peter Nightingale and Chim Lang and Dana Dawson and Michael Frenneaux",

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AU - Singh, Satnam

AU - Beadle, Roger

AU - Cameron, Donnie

AU - Rudd, Amelia

AU - Bruce, Maggie

AU - Jagpal, Baljit

AU - Schwarz, Konstantin

AU - Brindley, Gemma

AU - Mckiddie, Fergus

AU - Nightingale, Peter

AU - Lang, Chim

AU - Dawson, Dana

AU - Frenneaux, Michael

PY - 2014/11

Y1 - 2014/11

N2 - ABSTRACT Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.

AB - ABSTRACT Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.

U2 - 10.2217/fca.14.62

DO - 10.2217/fca.14.62

M3 - Article

C2 - 25495811

SN - 1744-8298

VL - 10

SP - 693

EP - 698

JO - Future cardiology

JF - Future cardiology

IS - 6

ER -

Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome

Abstract

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