Rapid and reversible impairment of episodic memory by a high-fat diet in mice

Fiona H McLean; Christine Grant; Amanda C Morris; Graham W Horgan; Alex  Polanski; Kevin Allan; Fiona M Campbell; Rosamund Langston; Lynda Williams

doi:10.1038/s41598-018-30265-4

Rapid and reversible impairment of episodic memory by a high-fat diet in mice

Fiona H McLean^* (Corresponding Author), Christine Grant, Amanda C Morris, Graham W Horgan, Alex Polanski, Kevin Allan, Fiona M Campbell, Rosamund Langston, Lynda Williams

^*Corresponding author for this work

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Abstract

Alzheimer’s disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer’s disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet. In addition, we show that these memory deficits are rapidly reversed by switching mice from a high-fat diet back to a low-fat diet. These findings have important implications for the contribution of nutrition to the development of cognitive decline and Alzheimer’s disease.

Original language	English
Article number	11976
Number of pages	9
Journal	Scientific Reports
Volume	8
DOIs	https://doi.org/10.1038/s41598-018-30265-4
Publication status	Published - 10 Aug 2018

Bibliographical note

The datasets generated during and/or analysed during the current study are
available from the corresponding author on reasonable request.

This work was supported by an EASTBIO BBSRC PhD studentship to F.H.M., L.M.W., C.G., A.C.M., G.W.H. and F.M.C. are supported by Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS).

Keywords

high-fat diet
obesity
mice
episodic memory
Alzheimer's disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-018-30265-4Licence: CC BY

Rapid and reversible impairment of episodic memory by a high-fat diet in mice
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Final published version, 1.39 MBLicence: CC BY

Fiona Campbell
- School of Medicine, Medical Sciences & Nutrition, The Rowett Institute of Nutrition and Health - Research Fellow
Person: Academic Related - Research

Cite this

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title = "Rapid and reversible impairment of episodic memory by a high-fat diet in mice",

abstract = "Alzheimer{\textquoteright}s disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer{\textquoteright}s disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet. In addition, we show that these memory deficits are rapidly reversed by switching mice from a high-fat diet back to a low-fat diet. These findings have important implications for the contribution of nutrition to the development of cognitive decline and Alzheimer{\textquoteright}s disease.",

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AU - Campbell, Fiona M

AU - Langston, Rosamund

AU - Williams, Lynda

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N2 - Alzheimer’s disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer’s disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet. In addition, we show that these memory deficits are rapidly reversed by switching mice from a high-fat diet back to a low-fat diet. These findings have important implications for the contribution of nutrition to the development of cognitive decline and Alzheimer’s disease.

AB - Alzheimer’s disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer’s disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet. In addition, we show that these memory deficits are rapidly reversed by switching mice from a high-fat diet back to a low-fat diet. These findings have important implications for the contribution of nutrition to the development of cognitive decline and Alzheimer’s disease.

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Rapid and reversible impairment of episodic memory by a high-fat diet in mice

Abstract

Bibliographical note

Keywords

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Fiona Campbell

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