Reasons for non-adherence to thromboprophylaxis prescribing guidelines in atrial fibrillation in Western Australia: A qualitative descriptive study of general practitioners' views

Eyob Alemayehu Gebreyohannes* (Corresponding Author), Sandra M. Salter, Leanne Chalmers, Luke Bereznicki, Kenneth Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background
A significant proportion of the atrial fibrillation (AF) population attending Australian primary care is not receiving guideline-adherent oral anticoagulant (OAC) treatment. This study aimed to explore reasons for non-adherence to thromboprophylaxis guidelines in AF from the perspectives of general practitioners (GPs) and to map these reasons to the Capability, Opportunity, Motivation-Behaviour (COM-B) model to identify potential opportunities to support practice change.

Methods
An exploratory qualitative descriptive study among GPs practising in Western Australia was conducted using semi-structured interviews, from November 2020 to February 2021. The Framework Method was employed to facilitate thematic analysis, using NVivo software. Interview responses were also mapped to the COM-B model.

Results
Nine of the 10 GPs initially consented participated in the semi-structured interview (Male = 56%, median age = 52 years, data saturation reached with 6 participants). Two themes emerged from analysis of the interview transcripts: (1) GPs' decision-making process and (2) Patient refusal to take OACs. The COM-B model mapping identified behavioural factors that could impact adherence: capability (GPs' knowledge and understanding of AF guideline recommendations), opportunity (access to a cardiologist, and patients' refusal to take OACs), and motivation (using formal bleeding risk assessment tools).

Conclusion
GPs identified various reasons contributing to non-adherence to thromboprophylaxis guidelines in patients with AF. Multifaceted interventions should consider behavioural opportunities to improve adherence, including education and training, electronic decision support, clinical audits by allied health professionals, partnership between general practices and local hospitals, and cardiologist-led interventions to support GPs. Further studies are needed to capture patients' reasons for refusing OACs.
Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalThrombosis Research
Volume208
Early online date2 Nov 2021
DOIs
Publication statusPublished - 1 Dec 2021

Bibliographical note

Acknowledgements
Mr. Eyob Alemayehu Gebreyohannes is a Ph.D. student and a recipient of the University of Western Australia International Fee Scholarship and University Postgraduate Award. Mr. Gebreyohannes would like to acknowledge the University of Western Australia for supporting his studies.

Funding
This study was funded by the University of Western Australia HDR (Higher Degree by Research) grant (PG 10402154).

Data Availability Statement

Supplementary data to this article can be found online at https://doi.org/10.1016/j.thromres.2021.10.025.

Keywords

  • atrial fibrillation
  • oral anticoagulant
  • general practice
  • primary care
  • guideline Adherence
  • qualitative

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