Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children

Jill King, Zoi-Dorothea Pana, Thomas Lehrnbecher, Adilia Warris, William J. Steinbach

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45 Citations (Scopus)
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Invasive fungal diseases (IFD) are devastating opportunistic infections that result in significant morbidity and mortality in a broad range of pediatric patients, particularly those with a compromised immune system. Recognition can be difficult, with non specific clinical signs and symptoms or isolated fever frequently the only presenting features. A high index of clinical suspicion in patients at increased risk of IFD is therefore necessary, and this requires knowledge of the pediatric patient population at risk, additional predisposing factors within this population, and the clinical signs and symptoms of IFD. This review aims to summarize our current knowledge regarding the recognition and clinical presentation of IFD in neonates and children.
Original languageEnglish
Pages (from-to)S12-S21
Number of pages10
JournalJournal of the Pediatric Infectious Diseases Society
Issue numberSuppl 1
Early online date31 Aug 2017
Publication statusPublished - Sept 2017

Bibliographical note

AW and JK are supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen


  • invasive fungal disease
  • clinical presentation
  • invasive aspergillosis
  • invasive candidiasis
  • pediatric patients


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