Recurrence risk of preterm birth in subsequent singleton pregnancy after preterm twin delivery

Jelle M. Schaaf*, Michel H.P. Hof, Ben Willem J. Mol, Ameen Abu-Hanna, Anita C.J. Ravelli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Objective: The purpose of this study was to investigate the recurrence risk of preterm birth (<37 weeks' gestation) in a subsequent singleton pregnancy after a previous nulliparous preterm twin delivery. Study Design: We included 1957 women who delivered a twin gestation and a subsequent singleton pregnancy from the Netherlands Perinatal Registry. We compared the outcome of subsequent singleton pregnancy of women with a history of preterm delivery to the pregnancy outcome of women with a history of term twin delivery. Results: Preterm birth in the twin pregnancy occurred in 1075 women (55%) vs 882 women (45%) who delivered at term. The risk of subsequent spontaneous singleton preterm birth was significantly higher after preterm twin delivery (5.2% vs 0.8%; odds ratio, 6.9; 95% confidence interval, 3.1-15.2). Conclusion: Women who deliver a twin pregnancy are at greater risk for delivering prematurely in a subsequent singleton pregnancy.

Original languageEnglish
Pages (from-to)279.e1-279.e7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
Publication statusPublished - Oct 2012


  • preterm birth
  • recurrence risk
  • singleton pregnancy
  • twin pregnancy


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