Reducing multiple births in assisted reproduction technology

Siladitya Bhattacharya, Mohan S Kamath

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Multiple pregnancy, a complication of assisted reproduction technology, is associated with poorer maternal and perinatal outcomes. The primary reason behind this is the strategy of replacing more than one embryo during an assisted reproduction technology cycle to maximise pregnancy rates. The solution to this problem is to reduce the number of embryos transferred during in-vitro fertilisation. The transition from triple- to double-embryo transfer, which decreased the risk of triplets without compromising pregnancy rates, was easily implemented. The adoption of a single embryo transfer policy has been slow because of concerns about impaired pregnancy rates in a fresh assisted reproduction technology cycle. Widespread availability of effective cryopreservation programmes means that elective single embryo transfer, along with subsequent frozen embryo transfers, could provide a way forward. Any such strategy will need to consider couples' preferences and existing funding policies, both of which have a profound influence on decision making around embryo transfer.
Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalBest Practice & Research Clinical Obstetrics & Gynaecology
Issue number2
Early online date4 Dec 2013
Publication statusPublished - Feb 2014


  • assisted reproduction technology
  • in-vitro fertilisation
  • multiple pregnancy
  • elective single embryo transfer


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